4
Fourth-Year Student Puts Her Energy into Bioinformatics
T
anya Cashorali, '08, likes the
excitement of being on the cut-
ting edge of genetic research.
The fourth-year student, who's working
toward a dual major in computer science
and biology, is on co-op in the Informatics
Program at Boston's Children's Hospital,
where she's researching the genetic
causes of Huntington's disease, autism,
asthma, and brain cancer.
"I've gotten a chance to work with
pioneers in the field, including the top
researchers in the Harvard and MIT
communities," says Cashorali. "They
were among the first to show that it's
possible to analyze white blood cells
rather than brain samples to draw accurate
conclusions on the genetic causes of
Huntington's disease." She's also been
working on a project to identify the genes
related to autism and asthma, using
another novel technique that incorpo-
rates not only genetic data but also
existing data from linkage peak analysis.
"Tanya has been working in this
multidisciplinary area where computing
meet genetics meets disease," says Isaac
Kohane, the director of the Children's
Hospital Informatics Program. "There
are few talented individuals that have
the training to be able to work at this
intersection, and Tanya has a facility for
understanding the biological concepts
and the questions being asked. She also
understands the software tools to the
point where she can not only use them,
but can improve them."
It's unusual for a student researcher
to be working on two different projects,
says Kohane, but few have Cashorali's
energy. She is currently writing two
papers related to her genetic research.
"One of the best things I've learned
from this co-op experience is how to go
about conducting this research--how to
think about problems and how to solve
them," she says. "Watching how these
researchers think is very cool."
Cashorali has also had an opportunity
to attend important industry conferences.
Kohane sent her to the National Institutes
of Health (NIH) in Bethesda, Maryland,
in July to attend a biomedical computing
meeting on Huntington's disease. Here,
she presented a poster on the hospital's
work in this area, which is supported by
the NIH, to the top principal investiga-
tors in biomedical computing.
Cashorali recently received a
five-month research grant funded by
Northeastern's provost's office and
CCIS, which will enable her to continue
her research at Children's Hospital.
Eventually, she plans to pursue a
PhD in bioinformatics and integrative
genomics, specializing in neuroscience
and integrating genetics into health care.
"The best thing about the dual
degree program is it allows you to com-
bine interests," Cashorali says. "There's
a ton of genetic and biological data out
there to be analyzed, but people who are
knowledgeable in the fields of both biology
and computer science are very rare.
Bioinformatics is an up-and-coming
field and it's exciting to be a part of it."
"One of the best things I've learned from this co-op experience
is how to go about conducting this research--how to think
about problems and how to solve them."
Tanya Cashorali makes an impact in genetic research during her co-op at Boston's Children's Hospital.